Case studies

Below is a list of case studies available from Catalysis Consulting.

• Introduction to Design of Experiments (DoE)
• Introduction to Principal Component Analysis (PCA)
• Combining Design of Experiments and Principal Component Analysis
• Case Study 1: Identifying an alternative catalyst systems for a Suzuki reaction reducing the catalyst cost of the process by more than $400,000.
• Case Study 2: Identifying an alternative catalyst systems for a Buchwald Hartwig amination reaction reducing the catalyst cost of the process by more than $280,000.
• Case Study 3: Rapid identification of an alternative catalyst system for a low yielding Suzuki reaction to support the delivery of 5 kg of an API intermediate through understanding.
• Case Study 4: Identifying an alternative catalyst and solvent system for a Suzuki reaction reducing the catalyst cost of the process by more than £140,000 while providing a more robust process which reliably double the isolated yield.
• Case Study 5: The elimination of a new impurity observed during the scale-up of a catalytic reaction was enabled based on mechanistic understanding of catalytic reactions.
• Case Study 6: Catalyst and Ligand selection
• Representative Biotransformations